Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation
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- 作者：Andrew T. Namanja ; Jianghai Wang ; Ralf Buettner ; Loren Colson ; Yuan Chen ; ychen@coh.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：2D ; two-dimensional ; HIES ; hyper-immunoglobulin E syndrome ; HMQC ; heteronuclear multiple quantum coherence ; CPMG ; Carr&ndash ; Purcell&ndash ; Meiboom&ndash ; Gill ; ND ; N-terminal domain ; CCD ; coiled-coil domain ; DBD ; DNA-binding domain ; LD ; linker domain ; SH2 ; Src homology 2 domain ; TAD ; transactivation domain ; CSP ; chemical shift perturbation ; ITC ; isothermal titration calorimetry ; uSTAT3 ; unphosphorylated STAT3 ; pSTAT3 ; phosphorylated STAT3
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：13 February 2016
- 年：2016
- 卷：428
- 期：3
- 页码：579-589
- 全文大小：926 K
文摘
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Demonstrated the feasibility of studying STAT transcription factors by NMR spectroscopy.
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Discovered allosteric communications between STAT3 domains.
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Revealed the mechanism of an HIES mutation that is not located at direct binding sites.