Splice variant insertions in the C-terminus impairs YAP’s transactivation domain
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- 作者：Megan L. Finch-Edmondsona ; phsmlf@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author ; Robyn P. Straussa ; b ; Robyn.Strauss@research.uwa.edu.au" class="auth_mail" title="E-mail the corresponding author ; Joshua S. Claytonc ; Joshua.Clayton@research.uwa.edu.au" class="auth_mail" title="E-mail the corresponding author ; George C. Yeoha ; b ; George.Yeoh@uwa.edu.au" class="auth_mail" title="E-mail the corresponding author ; Bernard A. Callusa ; d ; Bernard.Callus@uwa.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：YAP ; yes-associated protein ; TAD ; transcriptional activation domain ; hYAP ; human YAP ; aa ; Amino acid ; mYAP ; mouse YAP ; WT ; wild-type ; Con ; control ; EV ; empty vector
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：6
- 期：Complete
- 页码：24-31
- 全文大小：606 K
文摘
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Transcriptional activities of yes-associated protein (YAP) isoforms were compared.
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YAP’s WW domains and leucine zipper motif both contribute to transcriptional activity.
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Absence of YAP’s second WW domain weakens transcriptional potency.
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Disruption of YAP’s leucine zipper weakens the transactivation domain (TAD).
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Potency of the TAD from YAP α, β, γ, δ isoforms is cell-context dependent.