Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

详细信息    查看全文

• 作者：Kirstin-Friederike Heise^a ; ^{kirstin.heise@kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Nick Kortzorg^a ; Guilherme Bicalho Saturnino^b ; ^c ; Hakuei Fujiyama^a ; Koen Cuypers^a ; ^d ; Axel Thielscher^b ; ^c ; ^e ; Stephan P. Swinnen^a ; ^f
• 关键词：Transcranial alternating current stimulation ; High-density electrode montage ; Beta frequency ; Corticospinal excitability ; Neurosensory effects
• 刊名：Brain Stimulation
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：9
• 期：5
• 页码：700-704
• 全文大小：1374 K

文摘

To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation.

Methods

In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20 Hz vs. 30 s low-frequency transcranial random noise stimulation).

Results

Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage.

Conclusions

In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.