Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR

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• 作者：Megumi Funakoshi-Tago^a ; ^{tago-mg@pha.keio.ac.jp} ; Takuro Moriwaki^a ; Fumihito Ueda^a ; Hiroomi Tamura^a ; Tadashi Kasahara^a ; ^c ; Kenji Tago^b ; ^{ktago@jichi.ac.jp}
• 关键词：CIS ; cytokine-inducible Src homology 2 protein ; Csk ; C-terminal Src kinase ; Epo ; erythropoietin ; EpoR ; erythropoietin receptor ; ET ; essential thrombocytosis ; JAK2 ; Janus kinase 2 ; MPNs ; myeloproliferative neoplasms ; PI3K ; phosphoinositide 3-kinase ; PMF ; primary myelofibrosis ; PV ; polycythemia vera ; RT-PCR ; reverse transcriptase-polymerase chain reaction ; SH2 ; Src homology 2 ; SOCS ; Suppressors of cytokine signaling ; STAT5 ; signal transducer and activator of transcription 5 ; TAE ; Tris&ndash ; acetic
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：41-57
• 全文大小：3220 K
• 卷排序：31

文摘

CIS is a target gene of STAT5. CIS inhibits cell proliferation induced by Epo or JAK2 V617F mutant. Tyrosine phosphorylation of CIS is essential for its inhibitory effect.