A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM
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- 作者：Kyung oh Junga ; b ; c ; d ; Hyewon Youna ; c ; d ; e ; hwyoun@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Seung Hoo Kima ; c ; Young-Hwa Kima ; b ; c ; Keon Wook Kanga ; c ; June-Key Chunga ; b ; c ; d ; jkchung@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intracellular and intranuclear protein ; hTERT ; Tat peptide ; IgM antibody ; 64Cu ; Live cell imaging
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：26 August 2016
- 年：2016
- 卷：477
- 期：3
- 页码：483-489
- 全文大小：1599 K
文摘
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We developed new probes for imaging hTERT using Tat-conjugated IgM antibodies labeled with a fluorescent dye and radioisotope.
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This probes could be used to overcome limitation of conventional antibody imaging system in live cell imaging.
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This system could be applicable to monitor intracellular and intranuclear proteins in vitro and in vivo.