Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1
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- 作者：Young-Jin Parka ; 1 ; Eun Kyoung Kima ; b ; 1 ; Jung Yoon Baea ; Sook Moona ; Jin Kima ; jink@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human telomerase reverse transcriptase (hTERT) ; Early growth response (EGR)-1 ; Cathepsin D ; Invasion ; Oral squamous cell carcinoma (OSCC)
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：222-231
- 全文大小：3202 K
文摘
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This study is to unravel the mechanism through which hTERT promotes cancer invasion.
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hTERT induces cancer invasion via MMP-2, MMP-9 as well as cathepsin D.
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hTERT could inhibit cancer invasion through modulating cathepsin D via EGR-1.
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The first report on EGR-1 is regulated by hTERT in oral squamous cell carcinoma.