Investigating Leber's hereditary optic neuropathy: Cell models and future perspectives

详细信息    查看全文

• 作者：Elona Jankauskaitė^a ; Ewa Bartnik^a ; ^b ; Agata Kodroń^a ; ^{agatakodron@wp.pl}
• 关键词：CRISPR ; Clustered Regularly Interspaced Short Palindromic Repeats ; EBV ; Epstein Barr virus ; LHON ; Leber's hereditary optic neuropathy ; RGC ; retinal ganglion cells ; EtBr ; ethidium bromide ; mitoTALENs ; mitochondria targeted transcription-activator-like effector nucleases
• 刊名：Mitochondrion
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：Complete
• 页码：19-26
• 全文大小：363 K
• 卷排序：32

文摘

LHON is the most common mitochondrial disease. The tissue affected in LHON (optic nerve) is not available for testing. Lymphoblasts, fibroblasts and cybrids are the most common models to study LHON. Different approaches to study LHON are discussed.