Interleukin-33, friend and foe in type-2 immune responses
详细信息 查看全文
- 作者：Clare Hardman ; Graham Ogg graham.ogg@ndm.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Immunology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：16-24
- 全文大小：706 K
文摘
- •
Primarily located in the nucleus, IL-33 is an alarmin and transcription factor.
- •
IL-33 and ST2 polymorphisms are implicated in a wide range of diseases.
- •
IL-33 drives pro-inflammatory type-2 immune responses.
- •
IL-33 can also promote anti-inflammatory responses and wound healing.
- •
IL-33 is regulated post-translationally by proteases, oxidation and decoy receptor.