刊名:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
出版年:2017
出版时间:February 2017
年:2017
卷:1860
期:2
页码:218-226
全文大小:826 K
卷排序:1860
文摘
Glutaredoxin ROXY19 interacts simultaneously with TGA transcription factors and with the co-repressor TOPLESS. Mutating the conserved ALWL motif into an ALWA motif renders ROXY1 and ROXY19 unable to interact with TOPLESS. Mutating the ALWL motif into an ALWA motif renders ROXY19 unable to repress transcription. Proteins that compete with ROXY19 for binding to TOPLESS interfere with the repressive function of ROXY19. Our conclusion: ROXYs repress transcription by bridging TGA factors with TOPLESS at specific target promoters.