Transthyretin as a new transporter of nanoparticles for receptor-mediated transcytosis in rat brain microvessels
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- 作者：So Yeun Kima ; Eun-Sook Choib ; Hyo-Jung Leeb ; Cheil Moona ; cmoon@dgist.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Eunjoo Kimb ; ejkim@dgist.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Receptor-mediated transcytosis ; Transthyretin ; Blood&ndash ; brain barrier (BBB) ; Drug delivery ; Nanomedicine
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：136
- 期：Complete
- 页码：989-996
- 全文大小：1742 K
文摘
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We screened transcytotic proteins that could guide nanoparticles through the blood–brain barrier.
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Not all transcytotic proteins could direct transcytosis of nanoparticles.
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Transthyretin is proposed as a new transporter for nanoparticles across blood–brain barrier.