Analysis of allergic immune responses in humanized mice
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- 作者：Iris Bellinghausen ; iris.bellinghausen@unimedizin-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Joachim Saloga
- 关键词：APC ; allophycocyanin ; DC ; dendritic cells ; GARP ; Glycoprotein A Repetitions Predominant ; IMDM ; Iscove modified Dulbecco medium ; NOD ; nonobese diabetic ; PAF ; platelet-activating factor ; PE ; phycoerythrin ; SCID ; severe combined immunodeficiency ; SIT ; allergen-specific immunotherapy ; Treg ; regulatory T cells ; Tr1 ; type 1 regulatory T cells
- 刊名：Cellular Immunology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：7-12
- 全文大小：478 K
文摘
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The mechanisms of IgE-mediated allergic diseases are not fully understood.
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The mechanisms of therapeutic approaches are also only partially elucidated.
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The transferability of experimental results from mice to men is limited.
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Humanized mice provide a valuable tool to analyze modulation of allergic diseases.