The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila
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- 作者：Yujun Zhanga ; 1 ; Deqing Konga ; 1 ; Lars Reichlb ; Nina Vogtc ; Fred Wolfb ; Jö ; rg Groß ; hansa ; jgrossh@gwdg.de" class="auth_mail
- 关键词：Cadherin ; Gastrulation ; Morphogenesis ; Cell intercalation ; N-glycosylation ; ER quality control ; Congenital disorder of glycosylation (CDG)
- 刊名：Developmental Biology
- 出版年：15 June 2014
- 年：2014
- 卷：390
- 期：2
- 页码：208-220
- 全文大小：14020 K
文摘
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The ER glucosyl transferase xit is specifically required for mesoderm invagination.
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xit is required for epithelial cell intercalation during germ band extension.
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xit is required for complete N-glycosylation of E-Cadherin.
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N-glycosylation is involved in E-Cadherin localisation and function.
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Partial N-glycosylation of E-Cadherin does not affect total E-Cad protein amount.