Initial research on the relationship between let-7 family members in the serum and massive cerebral infarction
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- 作者：Zhe Gonga ; b ; Shaoyun Zhaoa ; b ; Jing Zhanga ; Xiaoge Xua ; Wenjuan Guana ; Lijun Jinga ; Peidong Liuc ; Jingjing Lua ; Junfang Tenga ; Tao Penga ; realptdq@126.com" class="auth_mail" title="E-mail the corresponding author ; Yanjie Jiaa ; jiayanjie1971@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Massive cerebral infarction ; Hemorrhagic transformation ; Let-7 ; IL-6 ; hs-CRP ; Inflammation
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：361
- 期：Complete
- 页码：150-157
- 全文大小：825 K
文摘
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Let-7f expressed in serum is associated with massive cerebral infarction (MCI) without hemorrhagic transformation (HT).
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IL-6 and hs-CRP were altered in MCI without HT.
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IL-6 is a direct target gene for let-7f, and let-7f specifically inhibits IL-6.