The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy
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- 作者：Q. Tiana ; Q. Xiaoa ; W. Yub ; M. Gua ; N. Zhaob ; Y. Lü ; a ; lyu_yang@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; AP-1 ; activator protein-1 ; BBB ; blood&ndash ; brain barrier ; COX-2 ; cicloossigenasi-2 ; DMSO ; dimethyl sulfoxide ; ELISA ; enzyme-linked immunosorbent assay ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; MAPK ; mitogen-activated protein kinase ; NF-kB ; nuclear factor-kappa B ; NMDA ; N-methyl-d-aspartate ; P-TAK1 ; phosphorylated TAK1 ; RT-PCR ; real-time polymerase chain reaction ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TAK1 ; transforming growth factor beta-ac
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：325
- 期：Complete
- 页码：111-123
- 全文大小：3681 K
文摘
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TRAF6 and TAK1 are upregulated after epilepsy.
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10">The early inhibition of TAK1 can significantly reduce the seizure durations.
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15">The inhibition of TAK1 confers neuroprotection after epilepsy in rats.