10">BIX02189 inhibits TGF-β1-induced EMT and cell migration in A549 lung cancer cells.
15">The inhibitory effect of BIX02189 is independent of its action as a MEK5 inhibitor.
BIX02189 directly binds to TβRI and suppresses its kinase activity.
BIX02189 blocks the metastatic spread of A549 cells in a xenograft mouse model.
BIX02189 may have use as a potential therapeutic agent for human lung cancer.