Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion

详细信息    查看全文

• 作者：Richard Van Krieken ; Guang Chen ; Bo Gao ; Jolene Read ; Hassan A. Al Saleh ; Renzhong Li ; Khalid Al-Nedawi ; Joan C. Krepinsky ; ^{krepinj@mcmaster.ca}
• 关键词：TGF-β1 ; transforming growth factor beta 1 ; SREBP-1 ; sterol regulatory element binding protein-1 ; TβRI ; TGF-β receptor I
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：158-167
• 全文大小：1116 K
• 卷排序：29

文摘

SREBP inhibition decreases cell surface expression of TGFβ receptor I in kidney mesangial cells. SREBP does not regulate receptor transcription or its proteasomal/lysosomal degradation. SREBP-1 serves as a novel cell surface retention factor for the TGFβ type I receptor. Profibrotic responses to TGFβ are prevented by SREBP inhibition. Targeting SREBP may serve as a novel therapy for fibrotic kidney disease.