Red cell storage age policy for patients with sickle cell disease: A survey of transfusion service directors in the United States

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• 作者：Matthew S. Karafin^a ; ^b ; ^{matthew.karafin@bcw.edu" class="auth_mail" title="E-mail the corresponding author} ; Arun K. Singavi^b ; Mehraboon S. Irani^a ; Kathleen E. Puca^a ; Lisa Baumann Kreuziger^a ; Pippa Simpson^b ; Joshua J. Field^a ; ^b
• 关键词：Transfusion practice ; Sickle cell disease ; Red cell storage age
• 刊名：Transfusion and Apheresis Science
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：54
• 期：1
• 页码：158-162
• 全文大小：304 K

文摘

In patients with sickle cell disease (SCD), the effects of the red cell storage lesion are not well defined. The objective of this study was to determine the prevalence of transfusion services that limit red cell units by storage age for patients with SCD. We developed a 22 question survey of transfusion service director opinions and their corresponding blood bank policies. Target subjects were systematically identified on the AABB website. Responses were recorded in SurveyMonkey and summarized using standard statistical techniques. Ninety transfusion service directors responded to the survey. Response rate was 22%. Only 23% of respondents had storage age policies in place for patients with SCD, even though 36% of respondents consider older units to be potentially harmful in this patient population. Of those with a policy, a less-than 15 day storage age requirement was most often used (75%), but practices varied, and most respondents (65%) agreed that evidence-based guidelines regarding storage age are needed for patients with SCD. Policies, practices and opinions about the risks of older units for patients with SCD vary. As patients with SCD may have unique susceptibilities to features of the red cell storage lesion, prospective studies in this population are needed to determine best practice.