Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons
详细信息 查看全文
- 作者：Saori R. Yoshii1 ; 2 ; 8 ; Akiko Kuma1 ; 2 ; 3 ; 8 ; Takumi Akashi4 ; Taichi Hara1 ; 9 ; Atsushi Yamamoto1 ; 2 ; 5 ; Yoshitaka Kurikawa2 ; Eisuke Itakura1 ; 10 ; Satoshi Tsukamoto6 ; Hiroshi Shitara7 ; Yoshinobu Eishi4 ; Noboru Mizushima1 ; 2 ; 11 ; nmizu@m.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：autophagy ; neonate ; Atg5 ; hypogonadism ; hormone ; anemia ; iron deficiency
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：39
- 期：1
- 页码：116-130
- 全文大小：4512 K
文摘
- •
Atg5-null neonates can survive if autophagy is restored in neurons
- •
The rescued Atg5-null mice develop multiple organ abnormalities
- •
These mice show reduced pituitary gland hormones and hypogonadism
- •
These mice develop hypochromic anemia due to iron malabsorption