We stereotaxically injected lenti-PA28γ virus into the striatum of mutant YAC128 HD transgenic mice and littermate controls.
YAC128 mice showed significant increase of their peptidyl-glutamyl preferring hydrolytic (PGPH) proteasome activity.
The number of inclusion bodies was reduced in the striatum of mutant YAC128 mice after lenti-PA28γ gene transfer.
YAC128 mice showed increased levels of BDNF mRNA, pro-BDNF, and BDNF protein after lenti-PA28γ gene transfer.
YAC128 mice showed significant improvement of latency to fall on the rota-rod test after lenti-PA28γ gene transfer.