Horizontal gene transfer of a Chlamydial tRNA-guanine transglycosylase gene to eukaryotic microbes
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- 作者：Sam Manna ; sam_manna@y7mail.com" class="auth_mail" title="E-mail the corresponding author ; Ashley Harman
- 关键词：TGTase ; tRNA-guanine transglycosylase ; E-TGTase ; Eukaryotic tRNA-guanine transglycosylase ; B-TGTase ; Bacterial tRNA-guanine transglycosylase ; BL-TGTase ; Bacterial-like tRNA-guanine transglycosylase ; HGT ; Horizontal gene transfer
- 刊名：Molecular Phylogenetics and Evolution
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：94
- 期：part_PA
- 页码：392-396
- 全文大小：812 K
文摘
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We present the evolutionary origin of a new class of tRNA-guanine transglycosylases.
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These enzymes horizontally acquired by eukaryotic microbes from Chlamydiae bacteria.
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Drugs have been developed against bacterial tRNA-guanine transglycosylases.
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The presence of these enzymes in pathogenic protozoa serve as putative drug targets.
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Horizontal gene transfer represents are untapped resource for possible drug targets.