T1AM is an endogenous thyroid hormone (TH) metabolite inducing a reversible body temperature decline.
10">Transient receptor potential melastatin 8 (TRPM8) is expressed in human corneal epithelial cells.
15">We studied TRPM8 and T1AM in regulating [Ca2 +]i and TRPV1 interaction in HCEC.
PCR, immunohistochemistry, Ca2 + imaging, planar patch-clamp technique, and heterologous TRPM8 expressed cells
TRPM8 activation suppressed TRPV1 activation by either capsaicin or exposure to a 450 mOsm hypertonic stress.