Evaluation of the antimicrobial activity of some chloro complexes of imidazole-2-carbaldehyde semicarbazone: X-ray crystal structure of cis-NiCl2(H2L)(H2O)
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- 作者：Marí ; a C. Rodrí ; guez-Argü ; elles ; S ; ra Mosquera-Vá ; zquez ; Jesú ; s Sanmartí ; n-Matalobos ; Ana M. Garcí ; a-Deibe ; Corrado Pelizzi ; Franca Zani
- 关键词：Imidazole ; Semicarbazone ; Zinc ; Copper ; Nickel ; Cobalt ; Antimicrobial activity
- 刊名：Polyhedron
- 出版年：2010
- 出版时间：1 February 2010
- 年：2010
- 卷：29
- 期：2
- 页码：864-870
- 全文大小：343 K
文摘
Some first row transition metal(II) complexes of imidazole-2-carbaldehyde semicarbazone (H2L) have been synthesised and characterised. Single crystal X-ray diffraction studies have revealed the molecular structure of the neutral complex NiCl2(H2L)(H2O). This latter complex shows a pseudo-octahedral geometry, with both chloride ions displaying a cis disposition. The asymmetry of this complex allows the formation of two enantiomers in the racemic crystal structure. The non-deprotonated semicarbazone ligand behaves as an N,N,O-donor, through the imidazole and imine N atoms and the Oketo atom. The coordinative behaviour of H2L in CuCl2(H2L)(H2O), ZnCl2(H2L)2·0.5EtOH and CoCl2(H2L)2·0.5H2O is reported as only N,O-donor. The antimicrobial activity of the semicarbazone ligand and its metal complexes has been tested against some representative bacteria and fungi. A moderate inhibitory activity of the cobalt complex was detected towards the assayed phytopathogenic fungi Alternaria tenuis and Sclerotinia minor (MIC 50 μg/mL).