Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
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- 作者：Masakazu Fujii ; Angé ; lica Amanso ; Thalita B. Abrahã ; o ; Bernard Lassè ; gue ; Kathy K. Griendling ; kgriend@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Akt ; protein kinase B ; Atg ; autophagy-related gene ; ECM ; extracellular matrix ; 4E-BP1 ; eukaryotic initiation factor 4E binding protein 1 ; eIF4E ; eukaryotic translation initiation factor 4E ; Hsc70 ; heat shock cognate protein 70 ; LC3B ; microtubule-associated protein 1A/1B-light chain 3 ; MASMs ; mouse aortic smooth muscle cells ; MMP ; matrix metalloproteinase ; mTOR ; mechanistic target of rapamycin ; PI3K ; phosphoinositide-3-kinase ; Poldip2 ; polymerase delta interacting protein 2 ; PRAS40 ; proline-rich
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：21-29
- 全文大小：1122 K
文摘
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Accumulation of collagen I is increased in Poldip2+/− MASMs.
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Poldip2+/− MASMs exhibit reduced autophagic flux.
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The PI3K/Akt/mTOR signaling pathway is activated basally in Poldip2+/− MASMs.
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Activation of this pathway contributes to accumulation of extracellular collagen.
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Poldip2+/− upregulates β1-integrin upstream of PI3K.