The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass
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- 作者：Oren Rom ; orenrom@tx.technion.ac.il" class="auth_mail" title="E-mail the corresponding author ; Abraham Z. Reznick
- 关键词：4E BP ; eukaryotic translation initiation factor-4E-binding protein ; Akt ; protein kinase B ; BCAA ; branched-chain amino acids ; CKD ; chronic kidney disease ; CLA ; conjugated linoleic acids ; COPD ; chronic obstructive pulmonary disease ; CS ; cigarette smoke ; CSA ; cross-sectional area ; DHA ; docosahexaenoic acid ; E1 ; ubiquitin-activating enzyme ; E2 ; ubiquitin-conjugating enzyme ; E3 ; ubiquitin-ligase enzyme ; eIF3-f ; eukaryotic translation initiation factor 3-subunit F ; EPA ; eicosapentaenoic acid ; ERK ; ext
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：218-230
- 全文大小：959 K
文摘
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MuRF-1 and MAFbx regulate pathological and physiological skeletal muscle atrophy.
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MuRF-1 and MAFbx are regulated by the FOXO, MAPK and NF-kB signaling pathways.
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Clinical evidence for MuRF-1 and MAFbx role in common human pathologies is lacking.
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Lifestyle factors (nutrition, exercise, smoking, etc.) affect MuRF-1 and MAFbx regulation.
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Inhibitors of MuRF-1 and MAFbx expression prevent muscle loss in experimental models.