Exploring accessibility of structural elements of the mammalian 40S ribosomal mRNA entry channel at various steps of translation initiation
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- 作者：Dmitri E. Sharifulina ; Yulia S. Bartulia ; Maria I. Meschaninovaa ; Aliya G. Ven'yaminovaa ; Dmitri M. Graifera ; b ; Galina G. Karpovaa ; b ; karpova@niboch.nsc.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Eukaryotic translation initiation ; Mammalian ribosomal protein uS3 ; Translation initiation factors ; 18S ribosomal RNA ; Restructuring mRNA entry channel
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1864
- 期：10
- 页码：1328-1338
- 全文大小：1329 K
文摘
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RNA-binding fragment of rp uS3 is shielded by eIF3j in 48S preinitiation complexes.
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Ribosomal eIF3j and mRNA sites overlap since third triplet of mRNA coding sequence.
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Binding of eIF3j and DHX29 to 40S subunits promotes rigid state of 18S rRNA helix 16.