Role of XPD in cellular functions: To TFIIH and beyond

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• 作者：Bennett Van Houten^a ; ^{vanhoutenb@upmc.edu" class="auth_mail" title="E-mail the corresponding author} ; Jochen Kuper^b ; ^{jochen.kuper@virchow.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author} ; Caroline Kisker^b ; ^{caroline.kisker@virchow.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ANT2 ; an adenine nucleotide translocase that exchanges mitochondrial ATP with cytosolic ADP ; CDK ; cyclin dependent kinase ; CAK ; CDK-activating kinase complex ; CIA ; cytoplasmic FeS assembly ; CIA01/2 ; cytosolic iron-sulfur assembly component ½ ; CS ; Cockayne syndrome ; ERCC2 ; excision repair cross complementing 2 XPD ; ERK2 ; extracellular signal-regulated kinase 2 ; ISC ; iron-sulfur cluster ; Mia40 ; redox-assisted folding processes within mitochondria also called import receptor CHCHD4 ; MIP18/FA
• 刊名：DNA Repair
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：44
• 期：Complete
• 页码：136-142
• 全文大小：1710 K

文摘

XPD, as part of the TFIIH complex, has classically been linked to the damage verification step of nucleotide excision repair (NER). However, recent data indicate that XPD, due to its iron-sulfur center interacts with the iron sulfur cluster assembly proteins, and may interact with other proteins in the cell to mediate a diverse set of biological functions including cell cycle regulation, mitosis, and mitochondrial function. In this perspective, after first reviewing the function and some of the key disease causing variants that affect XPD’s interaction with TFIIH and the CDK-activating kinase complex (CAK), we investigate these intriguing cellular roles of XPD and highlight important unanswered questions that provide a fertile ground for further scientific exploration.