The role of mitochondrial sirtuins in health and disease
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- 作者：Brenna Osborne ; Nicholas L. Bentley ; Magdalene K. Montgomery ; Nigel Turner ; n.turner@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：AceCS2 ; acetyl-CoA synthetase 2 ; ATP ; adenosine triphosphate ; AMPK ; AMP-activated protein kinase ; ANT2/ANT3 ; adenine nucleotide translocase 2 and 3 ; BMI ; body mass index ; CtBP ; C-terminal-binding protein ; CPS1 ; carbamoyl phosphate synthetase 1 ; CR ; calorie restriction ; FOXO3a ; forkhead box O3 ; GAPDH ; glyceraldehyde phosphate dehydrogenase ; GDH ; glutamate dehydrogenase ; G6PD ; glucose-6-phosphate dehydrogenase ; HI/HA ; hyperinsulinism/hyperammonemia syndrome ; HMGCS2 ; 3-hydroxy-3-methylglutaryl CoA
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：164-174
- 全文大小：1161 K
文摘
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SIRT3, SIRT4 and SIRT5 modulate acyl modifications such as acetylation and succinylation.
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Mitochondrial SIRTs are implicated in metabolism, mitochondrial fidelity, and cell stress.
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Alterations in the expression/activity of SIRT3, SIRT4, SIRT5 are linked with disease.
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Questions remain about the potential of mitochondrial SIRTs as therapeutic targets.