EYA4 gene functioned as a novel tumor suppressor gene in PDAC cells.
EYA4 exerted its biological functions on PDAC cells in an ID2-dependent manner.
EYA4 repressed ID2 expression via blocking β-catenin nuclear translocation mediated by β-catenin Ser675 dephosphorylation.
EYA4 expression was an independent prognostic molecular marker for pancreatic ductal adenocarcinoma.