Lipopolysaccharide and heat stress impair the estradiol biosynthesis in granulosa cells via increase of HSP70 and inhibition of smad3 phosphorylation and nuclear translocation

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• 作者：Hui Li^a ; Shuangshuang Guo^b ; Liuping Cai^a ; Weiming Ma^b ; Zhendan Shi^a ; ^{zdshi@scau.edu.cn}
• 关键词：Lipopolysaccharide ; Heat stress ; Granulosa cell ; Estradiol ; HSP70 ; Smad3
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：130-141
• 全文大小：1853 K
• 卷排序：30

文摘

LPS and heat stress induce downregulation of FSHR and CYP19A1 expressions in GCs via upregulation of HSP70. Inhibition of HSP70 activity can restore the FSHR and CYP19A1 expressions in GCs. Activation of HSP70 alone can mimic the effects of LPS and heat stress on GCs. HSP70 exert its inhibitory effects by indirect inhibition of Smad3 phosphorylation and nuclear translocation.