Chromosomal analyses of 1510 couples who have experienced recurrent spontaneous abortions

详细信息    查看全文

• 作者：Erdal Tunç ; Nilgü ; n Tanrıverdi ; Osman Demirhan ; ^{osdemir@cu.edu.tr" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; Dilara Sü ; leymanova ; Nesrin Ç ; etinel
• 关键词：aberrations ; chromosome ; lymphocytes ; recurrent miscarriages ; translocations
• 刊名：Reproductive BioMedicine Online
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：32
• 期：4
• 页码：414-419
• 全文大小：605 K

文摘

In this retrospective study, karyotype results of 1510 couples with a history of recurrent spontaneous abortion were evaluated. The study was conducted at Balcalı Hospital in Adana region of Turkey. For all cases, peripheral blood lymphocytes were cultured for chromosome study using the standard method. Chromosome aberrations were detected in 62 couples (4.1% of all couples). At an individual level, chromosome aberrations were found in a total of 65 cases (41 females and 24 male cases), with structural chromosomal aberrations in 58 cases including balanced translocations in 30 cases, Robertsonian translocations in 12 cases, deletions in seven cases, inversions in nine cases and numerical chromosome aberrations in seven cases. The results of the study indicated that structural aberrations, particularly translocations, were the most common type of aberration observed among couples who had experienced recurrent spontaneous abortions and that these couples might benefit from cytogenetic analyses.