Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae

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• 作者：Donata Wawrzycka¹ ; Katarzyna Markowska¹ ; Ewa Maciaszczyk-Dziubinska ; Magdalena Migocka ; Robert Wysocki ; ^{robert.wysocki@uwr.edu.pl}
• 关键词：aa ; amino acids ; As(III) ; arsenite ; As(V) ; arsenate ; Endo H ; endoglycosidase H ; ER ; endoplasmic reticulum ; fXa ; factor Xa protease ; L ; hydrophilic loop ; NP-40 ; Nonidet P-40 ; Sb(III) ; antimonite ; TM ; transmembrane segment
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：117-125
• 全文大小：1203 K
• 卷排序：1859

文摘

We experimentally determined the topology of the yeast arsenite permease Acr3. Acr3 contains ten transmembrane regions (TM). Both N- and C-terminus of Acr3 face the cytoplasm. An extra segment in the loop L8 is dispensable for Acr3 function. We present a homology structural model of Acr3.