Synthetic TLR4 agonists enhance functional antibodies and CD4+ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen
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- 作者：Susan L. Baldwina ; Will Roeffenb ; Susheel K. Singhc ; d ; Regis W. Tiendrebeogoc ; d ; Michael Christiansenc ; Elyse Beebea ; Darrick Cartera ; Christopher B. Foxa ; Randall F. Howarda ; Steven G. Reeda ; Robert Sauerweinb ; Michael Theisenc ; d ; mth@ssi.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Plasmodium falciparum ; GMZ2 ; Pfs48/45 ; Transmission blocking ; CD4 T-helper cells ; GLA ; SLA
- 刊名：Vaccine
- 出版年：2016
- 出版时间：27 April 2016
- 年：2016
- 卷：34
- 期：19
- 页码：2207-2215
- 全文大小：1280 K
文摘
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A multistage chimera consisting of transmission and asexual blood-stage antigens.
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This chimera consists of P. falciparum GMZ2 genetically fused to Pfs48/45-6C fragment.
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GMZ2 is in advanced clinical trials.
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The GMZ2-Pfs48/45-6C chimera elicits functional antibodies in small rodents.
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Formulations containing GLA or SLA elicited the strongest immune responses.