Mitochondrial impairment, apoptosis and autophagy in a rat brain as immediate and long-term effects of perinatal phencyclidine treatment — influence of restraint stress
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- 作者：Gordana Jevtića ; Tatjana Nikolića ; Aleksandar Mirčićb ; Tihomir Stojkovića ; Milica Velimirovića ; Vladimir Trajkovićc ; Ivanka Markovića ; Alexander M. Trbovichd ; Nevena V. Radonjića ; Nata&scaron ; a D. Petronijevića ; natasapetronijevic@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; natasa.petronijevic@med.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIF ; apoptosis-inducing factor ; ANOVA ; The Analysis Of Variance ; COX ; cytochrome c oxidase ; DCIP ; 2 ; 6-dichloroindophenol ; i.p. ; intraperitoneal ; NMDA ; N-methyl-d-aspartate ; LC3 ; microtubule associated protein 1 light chain 3 ; P ; postnatal day ; PCP ; phencyclidine ; PV ; + ; ; parvalbumin positive cells ; SCH ; schizophrenia ; S.E.M. ; standard error of the mean ; TEM ; transmission electron microscopy
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 April 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：87-96
- 全文大小：1441 K
文摘
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The mitochondrial dysfunction may be involved in the pathophysiology of SCH.
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Perinatal PCP treatment causes mitochondrial impairment.
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Mitochondrial dysfunction leads to apoptosis.
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Autophagy is present in PCP animal model.
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Restraint stress exacerbate PCP induced changes in the rat brain.