文摘
We conducted a prospective trial of alternative donor transplantation for severe aplastic anemia The regimen contained nonmyeloablative conditioning and post-transplantation cyclophosphamide for graft-versus-host disease prophylaxis The regimen allows use of haploidentical and unrelated donors All 16 patients are alive, transfusion independent, and without evidence of clonality This approach will be studied as 1 arm of next Blood and Marrow Transplant Clinical Trials Network trial for relapsed and refractory severe aplastic anemia