The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?
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- 作者：Kelly Ceyzé ; riata ; b ; Kelly.ceyzeriat@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Laurene Abjeana ; b ; Laurene.abjean@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Marí ; a-Angeles Carrillo-de Sauvagea ; b ; maria.carrillo@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Lucile Ben Haima ; b ; c ; Lucile.BenHaim@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Carole Escartina ; b ; carole.escartin@cea.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; ALS ; amyotrophic lateral sclerosis ; CNS ; central nervous system ; CNTF ; ciliary neurotrophic factor ; Cx43 ; connexin 43 ; DN ; dominant negative ; EGF ; epidermal growth factor ; ETC ; electron transport chain ; GFAP ; glial fibrillary acidic protein ; GPCR ; G-protein-coupled receptor ; HD ; Huntington&rsquo ; s disease ; HDAC ; histone deacetylase ; IL ; interleukin ; JAK ; janus kinase ; KO ; knock out ; Lcn2 ; lipocalin 2 ; LPS ; lipopolysaccharide ; Lys ; lysine ; MAPK ; mitogen-activated pr
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：330
- 期：Complete
- 页码：205-218
- 全文大小：1578 K
文摘
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Astrocyte reactivity occurs in virtually all brain diseases but is a heterogeneous response.
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The JAK–STAT3 pathway plays a key role in the control of astrocyte reactivity.
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STAT3 is a pleiotropic molecule operating multiple functions in reactive astrocytes.
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Specific states of reactivity are driven by complex signaling cascades around STAT3.