Artabolide, a novel polar auxin transport inhibitor isolated from Artemisia absinthium
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- 作者：Tsukasa Arai ; Yuta Toda ; Kiyotaka Kato ; Kensuke Miyamoto ; Tsuyoshi Hasegawa ; Kosumi Yamada ; Junichi Ueda ; Koji Hasegawa ; Tsuyoshi Inoue ; Hideyuki Shigemori
- 关键词：Artabolide ; ¦Á-Methylene-¦Ã-lactone ; Modified Mosher's method ; Polar auxin transport inhibitor ; X-ray crystal structure analysis
- 刊名：Tetrahedron
- 出版年：2013
- 出版时间：26 August, 2013
- 年：2013
- 卷：69
- 期：34
- 页码：7001-7005
- 全文大小：798 K
文摘
A new sesquiterpene with an ¦Á-methylene-¦Ã-lactone moiety, artabolide (1), and three known derivatives 2-4 were isolated from Artemisia absinthium. The structure of 1 was elucidated by 1D and 2D NMR analyses, and the absolute configuration was determined using the modified Mosher's method and X-ray crystal structural analysis. Approximately 2.5?¦Ìg/plant treatment of artabolide (1) exhibited ca. 50 % inhibition of polar auxin transport in radish hypocotyls, while 2-4 showed no significant inhibitory activity. Therefore, these results support the importance of the ¦Á-methylene-¦Ã-lactone moiety for the inhibition of polar auxin transport.