Influence of perfluorooctanoic acid on proteomic expression and cell membrane fatty acid of Escherichia coli

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• 作者：Meng Yang^a ; Jinshao Ye^b ; Huaming Qin^a ; ^{huamingqin@163.com} ; Yan Long^a ; Yi Li^a
• 关键词：Resistance mechanism ; PFOA ; Escherichia coli ; iTRAQ ; Proteomic analysis
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：220
• 期：part_PA
• 页码：532-539
• 全文大小：2083 K
• 卷排序：220

文摘

Relation between fatty acids and proteomics in E. coli exposed to PFOA was revealed. Palmitoleic acid was the biomarker reflected PFOA stress. Up-regulation of major catalytic enzymes involved in carbohydrate, lipid metabolism. Down-regulated proteins inhabited transport and energy metabolism under PFOA stress. Promotion of TCA cycle and fatty acid biosynthesis increased membrane permeability.