Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells
详细信息 查看全文
- 作者：Marc Le Veea ; Elodie Jouana ; Valé ; rie Lecureura ; Olivier Fardela ; b ; olivier.fardel@univ-rennes1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AhR ; aryl hydrocarbon receptor ; BCH ; 2-aminobicyclo-(2 ; 2 ; 1)-heptane-2-carboxylic acid ; CYP ; cytochrome P-450 ; DEP ; diesel exhaust particle ; DEPe ; diesel exhaust particle extract ; DMSO ; dimethyl sulfoxide ; EGR1 ; early growth response 1 ; ERK ; extracellular regulated kinase ; FAK ; focal adhesion kinase ; LAT ; L-type amino acid transporter ; MMP ; metalloproteinase ; mTORC1 ; mammalian target of rapamycin complex 1 ; p70S6K ; p70S6 kinase ; PAH ; polycyclic aromatic hydrocarbon ; PI3K ; phosphatidylinositol-3 k
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：74-85
- 全文大小：1336 K
文摘
- •
The amino acid transporter LAT1/CD98hc is up-regulated in DEPe-treated lung cells.
- •
10">The aryl hydrocarbon receptor is involved in DEPe-triggered induction of LAT1/CD98hc.
- •
15">DEPe enhances LAT1-mediated accumulation of leucine in lung cells.
- •
DEPe increases MMP-2 expression and activity in a CD98hc/FAK/ERK-dependent manner.