LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

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• 作者：Keitaro Hayashi^a ; Promsuk Jutabha^a ; Sumiko Maeda^b ; Yothaisong Supak^a ; Motoshi Ouchi^a ; Hitoshi Endou^c ; Tomoe Fujita^a ; Masayuki Chida^b ; Naohiko Anzai^a ; ^d ; ^{anzai-path@umin.ac.jp}
• 关键词：Thymic carcinoma ; Anticancer drug ; Transporter
• 刊名：Journal of Pharmacological Sciences
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：132
• 期：3
• 页码：201-204
• 全文大小：942 K
• 卷排序：132

文摘

L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown. Here we demonstrate that LAT1 is a critical transporter for human thymic carcinoma cells. LAT1 was strongly expressed in human thymic carcinoma tissues. LAT1-specific inhibitor significantly suppressed leucine uptake and growth of Ty82 human thymic carcinoma cell lines, suggesting that thymic carcinoma takes advantage of LAT1 as a quality transporter and that LAT1-specific inhibitor might be clinically beneficial in therapy for thymic carcinoma.