Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064
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- 作者：Jamie E. Moscovitza ; Bo Konga ; Kyle Buckleya ; Brian Buckleyb ; Grace L. Guoa ; b ; Lauren M. Aleksunesa ; b ; aleksunes@eohsi.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Asbt ; apical sodium-dependent bile acid transporter ; Baat ; bile acid CoA ; amino acid N-acetyltransferase ; Bal ; bile acid CoA ligase ; Bsep ; bile salt export pump ; Cyp ; cytochrome P450 ; Fgf ; fibroblast growth factor ; Fxr ; farnesoid X receptor ; I-babp ; ileal bile acid binding protein ; ICP ; intrahepatic cholestasis of pregnancy ; Mdr ; multidrug resistance protein ; Mrp ; multidrug resistance-associated protein ; Ntcp ; Na+-taurocholate cotransporting polypeptide ; Oatp ; organic anion-transporting polypepti
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：310
- 期：Complete
- 页码：60-67
- 全文大小：1108 K
文摘
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Ileal bile acid pathways are altered in pregnancy in an Fxr-dependent manner.
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Ileal Fxr/Fgf contributes to changes in hepatic bile acid synthesis and transport.
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Treatment of pregnant mice with an Fxr agonist restores bile acid homeostasis.