Increase in IS256 transposition in invasive vancomycin heteroresistant Staphylococcus aureus isolate belonging to ST100 and its derived VISA mutants
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- 作者：Sabrina Di Gregorioa ; Silvina Fernandeza ; Beatriz Perazzib ; Natalia Belloc ; Angela Famigliettib ; Marta Molleracha ; martamollerach@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：S. aureus ; IS256 transposition ; hVISA/VISA
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：197-202
- 全文大小：431 K
文摘
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We describe the increase IS256 transposition in hVISA isolate during antibiotic therapy.
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Subinhibitory concentration of vancomycin enhances the expression of IS256 transposase in VISA mutants.
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The insertion of IS256 into agr locus leads to the loss of agr locus function in one of the mutants.