The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects

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• 作者：Tsutomu Takahashi^a ; ^b ; ^{tsutomu@med.u-toyama.ac.jp" class="auth_mail} ; Yumiko Nakamura^a ; Yukako Nakamura^c ; Branko Aleksic^c ; Yoichiro Takayanagi^a ; Atsushi Furuichi^a ; Mikio Kido^a ; Mihoko Nakamura^a ; Daiki Sasabayashi^a ; Masashi Ikeda^b ; ^f ; Kyo Noguchi^e ; Kozo Kaibuchi^b ; ^d ; Nakao Iwata^b ; ^f ; Norio Ozaki^b ; ^c ; Michio Suzuki^a ; ^b
• 关键词：ANOVA ; analysis of variance ; CASH ; Comprehensive Assessment of Symptoms and History ; DISC1 ; Disrupted-in-Schizophrenia 1 ; HWE ; Hardy&ndash ; Weinberg equilibrium ; LOS ; lateral orbital sulcus ; MOS ; medial orbital sulcus ; MRI ; magnetic resonance imaging ; OFC ; orbitofrontal cortex ; SANS ; Scale for the Assessment of Negative Symptoms ; SAPS ; Scale for the Assessment of Positive Symptoms ; SNP ; single-nucleotide polymorphism ; TOS ; transverse orbital sulcus
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：3 June, 2014
• 年：2014
• 卷：51
• 期：Complete
• 页码：166-171
• 全文大小：608 K

文摘

An altered sulcogyral pattern in the orbitofrontal cortex (OFC) has been implicated in schizophrenia as a possible marker of abnormal neurodevelopment, while its genetic mechanism remains unknown. This magnetic resonance imaging study investigated the relationship between the polymorphism of YWHAE (rs28365859), a gene encoding 14-3-3epsilon that is a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule associated with neuronal development, and the OFC subtypes of the 鈥楬-shaped鈥?sulcus (Types I, II, and III) in a Japanese sample of 72 schizophrenia patients and 86 healthy controls. The schizophrenia patients had significantly increased Type III (p = 0.004) and decreased Type I (p = 0.013) expression on the right hemisphere compared to the controls. The subjects carrying the protective C allele showed a decrease in Type III (p = 0.005) and an increase in Type I (p = 0.017) compared to the G allele homozygotes, especially for the healthy subjects in the left hemisphere. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia.