Multi-contrast T₂^⁎-relaxometry upon visual stimulation at 3 T and 7 T

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• 作者：Moritz C. Berger^a ; Peter Bachert^a ; Jens Grö ; bner^a ; Armin M. Nagel^a ; ^b ; ^{a.nagel@dkfz.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Relaxometric fMRI ; BOLD ; ultrahigh field ; multi-contrast EPI ; visual stimulation ; signal model comparison
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：34
• 期：7
• 页码：864-874
• 全文大小：1135 K

文摘

This study aims to quantify the mean change of the effective transverse relaxation time T₂^⁎ in active brain regions of human volunteers at field strengths of B₀ = 3 T and 7 T. Besides the mono-exponential signal decay model an extended model is tested that considers mesoscopic field gradients across imaging voxels. Both models are checked for cross-talk and correlations between the parameters. A visual checkerboard-stimulation experiment with pause and stimulation periods of 50 s and six repetitions was performed on healthy volunteers. Eleven contrasts were acquired in about 1.47 s/1.43 s at 3 T/7 T using a segmented multi-contrast echo-planar imaging (EPI) sequence. Average BOLD-signal time courses were calculated in a multi-step (non-)linear least-squares process. Baseline T₂^⁎ values of 37.72 ms/24.99 ms (47.34 ms/33.71 ms) with stimulus-correlated changes ∆ T₂^⁎ of 1.32 ms/0.74 ms (1.99 ms/1.43 ms) resulted from the mono-exponential (extended) model for 3 T/7 T. A dependence of those values on the initial intensity S₀ was observed. Stimulus-correlated changes of S₀ in the order of 1% were measured at both field strengths. The mono-exponential model was found to be less prone to instabilities in the regression of both parameters. Signal alterations due to inflow were observed. Measured relaxation times agree with values from literature using repetitive stimulation. A strong dependence of the measured relaxation times on the inflow-related model parameter was found for both models. The extended model is applicable to dynamic neurofunctional measurements, but is currently limited due to the low number of contrasts acquired.