131 The experience of nebulised aztreonam lysine at the All Wales Adult CF Centre (AWACFC)

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• 作者：A. Rees ; R.I. Ketchell ; C. Bridges ; J. Duckers
• 刊名：Journal of Cystic Fibrosis
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：14
• 期：supp_S1
• 页码：S91
• 全文大小：68 K

文摘

To evaluate the experience of patients chronically colonised with Pseudomonas aeruginosa trialled on nebulised aztreonam lysine and their outcomes over a 6 month period at the AWACFC.

Methods

Patients’ FEV1 and BMI values were restrospectively collected for the 6 months pre and post aztreonam lysine and mean values were calculated. The total number of IV antibiotic days pre and post were also collected.

Results

Data for 27 patients (9 males) was collected, mean (SD) age 34.0 (11.5) years range 19 to 71 years. From the 27 patients trialled 1 patient failed the trial, 1 patient discontinued, 4 patients were transplanted and 1 patient died awaiting a transplant.

Conclusion

Aztreonam lysine was well tolerated within the adult population at the AWACFC. The majority of patients commenced on aztreonam lysine generally had severe lung disease and 4 of these went on to have transplants. This is likely to account for the lack of statistical significance for mean FEV₁ and BMI change. However it is reassuring that these patients appeared stable over a 6 month period. There was a statistically significant reduction in the number of post IV antibiotic days. The study is limited by the small number of patients included in the data and should be analysed in conjunction with a larger database.