Ras, ROS and Proteotoxic Stress: A Delicate Balance

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• 作者：Wanping Xu¹ ; Jane Trepel² ; Len Neckers¹ ;   ; ^{neckers@nih.gov}
• 刊名：Cancer Cell
• 出版年：2011
• 出版时间：13 September 2011
• 年：2011
• 卷：20
• 期：3
• 页码：281-282
• 全文大小：181 K

文摘

Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et?al. identify a novel strategy that utilizes this dependency to cause cell death.