Synthesis and biological activity of two pregnane derivatives with a triazole or imidazole ring at C-21
详细信息 查看全文
- 作者：Aylin Viviana Silva-Ortiza ; Eugene Bratoeffa ; 1 ; Marí ; a Teresa Ramí ; rez-Apanc ; Rocí ; o Garcí ; a-Becerrab ; David Ordaz-Rosadob ; Nancy Noyola-Martí ; nezb ; Rafael Castillo-Bocanegraa ; David Barrerab ; barrera1912@gmail.com" class="auth_mail" title="E-mail the corresponding author ; vidadav@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AR ; androgen receptor ; PR ; progesterone receptor ; VDR ; vitamin D receptor ; P4 ; progesterone
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：159
- 期：Complete
- 页码：8-18
- 全文大小：1761 K
文摘
- •
Pregnane derivatives with a triazole (T–OH) or imidazole (I–OH) moiety at C-21 were synthesized.
- •
The derivatives showed anticancer activity upon PC-3, MCF7 and SK-LU-1 cell lines.
- •
PC-3 cells were the most sensitive to I–OH treatment.
- •
Compound I–OH inhibited the mRNA CCND1 and CCNE1 expression.
- •
I–OH has weak antiprogestagenic activity.