Synthesis, characterization and biological evaluation of 99mTc/Re-tricarbonyl quinolone complexes
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- 作者：Theocharis E. Kydonakia ; b ; Evangelos Tsoukasc ; Filipa Mendesd ; Antonios G. Hatzidimitrioua ; Antó ; nio Paulod ; Lefkothea C. Papadopoulouc ; Dionysia Papagiannopouloub ; papagd@pharm.auth.gr" class="auth_mail" title="E-mail the corresponding author ; George Psomasa ; gepsomas@chem.auth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Quinolones ; Rhenium complexes ; Technetium-99m ; Imaging agents ; Biological activity
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：94-105
- 全文大小：1034 K
文摘
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[Re(I)(CO)3] complexes with the quinolones oxolinic acid and enrofloxacin (Herx) are prepared.
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The rhenium(I) complexes can bind to human or bovine serum albumin proteins.
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Intercalation is the most possible binding mode of the Re(I) complexes to DNA.
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[Re(CO)3(erx)(imidazole)] presents higher inhibitory topoisomerase IIα activity than free Herx.
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Tracer complex [99mTc(CO)3(erx)(im)] can enter K562 cancer cells.