Design and synthesis of a novel protected mixed ligand siderophore

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• 作者：Pingyu Ding ; Clara E. Schous ; Marvin J. Miller
• 关键词：Lake Trichonis ; Western Greece ; Focal mechanisms ; Strike-slip ; Earthquake ; Tectonics
• 刊名：Tetrahedron Letters
• 出版年：2008
• 出版时间：31 March 2008
• 年：2008
• 卷：49
• 期：14
• 页码：2306-2310
• 全文大小：142 K

文摘

A novel siderophore analog (4) has been designed to facilitate iron transport-mediated drug delivery and drug release. This mixed ligand siderophore analog includes three bidentate ligands intended to octahedrally coordinate iron (III). The ligands include a 2,3-dihydroxy benzoic acid moiety, N⁵-acetyl-N⁵-hydroxy-l-ornithine, and a β-N-hydroxy-,β-diaminopropionic acid derivative. The total synthesis of 15, a form of 4 that is suitably protected, yet contains a free carboxylic acid for subsequent drug conjugation, is described.