Reduced antibody responses against Plasmodium falciparum vaccine candidate antigens in the presence of Trichuris trichiura

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• 作者：Meral Esen^a ; ^b ; ¹ ; Benjamin Mordmü ; ller^a ; ^b ; ¹ ; ^{benjamin.mordmueller@uni-tuebingen.de} ; Pablo Martinez de Salazar^a ; ^b ; ¹ ; Ayola Akim Adegnika^a ; ^b ; ^c ; Selidji Todagbe Agnandji^a ; ^b ; Frieder Schaumburg^a ; ^b ; Aurore Bouyoukou Hounkpatin^a ; ^b ; Sina Brü ; ckner^a ; Michael Theisen^d ; ^e ; Sabine Bé ; lard^a ; ^b ; Ulysse Ateba Ngoa^a ; ^b ; ^c ; Saadou Issifou^a ; ^b ; Maria Yazdanbakhsh^c ; Peter G. Kremsner^a ; ^b
• 关键词：Vaccine ; Trichuris trichiura ; Antibody ; Helminth ; Malaria
• 刊名：Vaccine
• 出版年：2012
• 出版时间：14 December, 2012
• 年：2012
• 卷：30
• 期：52
• 页码：7621-7624
• 全文大小：315 K

文摘

Background

Helminth infections are highly prevalent in the tropics and may have an effect on immune responses to vaccines due to their immunomodulatory effect. The prevalence of helminth infections in young children, the target group for malaria and most other vaccines, is high. Therefore we assessed the influence of helminth infection on vaccine-induced immune responses in a phase I clinical trial of the malaria vaccine candidate GMZ2.

Methods

Twenty Gabonese preschool-age children were vaccinated with GMZ2, a blood stage malaria vaccine candidate. Humoral immune response against the vaccine antigens and parasitological status were assessed. Vaccine-specific antibody concentrations and memory B-cell numbers were compared in worm infected and non-infected participants.

Results

Antibody response to GMZ2 was 3.4-fold (95 % confidence interval: 1.6, 7.4) higher in Trichuris trichiura negative subjects compared to positive participants, whereas immunoglobulin subclass distribution was similar. Memory B-cell response was moderately increased in T. trichiura negative individuals, although the difference was not significant.

Conclusions

Future malaria vaccine development programs need to account for worm-mediated hyporesponsiveness of immune reactions.