Rare earth triflate catalysts in the synthesis of Vitamin E and its derivatives

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• 作者：Werner Bonrath ; Claus Dittel ; Lisa Giraudi ; Thomas Netscher ; Thomas Pabst
• 关键词：Vitamin E ; α ; -Tocopherol ; Antioxidant ; Metal triflates ; Rare earth metal triflates
• 刊名：Catalysis Today
• 出版年：2007
• 出版时间：15 March 2007
• 年：2007
• 卷：121
• 期：1-2
• 页码：65-70
• 全文大小：602 K

文摘

Vitamin E is known as the most important fat-soluble antioxidant in biological systems. The scale for commercially produced (all-rac)-α-tocopherol reaches over 25,000 tonnes per year. The known processes for the synthesis of α-tocopherol suffer from disadvantages like formation of by-products and waste-water problem. To overcome these drawbacks, new types of catalysts have been developed. These are rare earth metal triflates, e.g. Bi(OTf)₃, Ga(OTf)₃, Tm(OTf)₃ or Hf(OTf)₄. This new approach to Vitamin E or derivatives thereof has several advantages, based on high yields (above 94 % ) and selectivities.